Albendazole jẹ anthelmintic sintetiki eyiti o jẹ ti ẹgbẹ ti awọn itọsẹ benzimidazole pẹlu iṣẹ ṣiṣe lodi si ọpọlọpọ awọn kokoro ati ni ipele iwọn lilo ti o ga julọ tun lodi si awọn ipele agbalagba ti fluke ẹdọ.
Albendazole ni idapo pelu eelworm's microtubule amuaradagba ati ki o mu ipa kan.Lẹhin ti albenzene ni idapo pẹlu β- tubulin, o le ṣe idiwọ dimerization laarin albenzene ati α tubulin ti o pejọ sinu awọn microtubules.Microtubules jẹ ipilẹ ipilẹ ti ọpọlọpọ awọn ẹya sẹẹli.Ibaṣepọ Albendazole si nematodes tubulin jẹ pataki ti o ga ju isunmọ ti tubulin mammalian, nitorina majele si mammalian jẹ kekere.
Itọkasi ati itọju awọn kokoro arun ninu awọn ọmọ malu ati ẹran bii:
Awọn kokoro inu inu:Bunostomum, Cooperia, Chabertia, Haemonchus, Nematodirus, Oesophagostomum, Ostertagia, Strongyloides ati Trichostrongylus spp.
Awọn kokoro ẹdọfóró:Dictyocaulus viviparus ati D. filaria.
Tapeworms:Monieza spp.
Ẹdọ-ẹdọ:agbalagba Fasciola hepatica.
Albendazole tun ni ipa ovicidal.
Isakoso ni awọn ọjọ 45 akọkọ ti oyun.
Awọn aati hypersensitivity.
Fun ẹnu isakoso.
Fun roundworms, tapeworms:
Eran-malu / efon / ẹṣin / agutan / ewurẹ: 5mg/kg bodyweight
Aja / ologbo: 10 si 25mg/kg iwuwo ara
Fun flukes:
Ẹran-ọsin / efon: 10mg / kg bodyweight
Agutan/ewúrẹ: 7.5mg/kg bodyweight
Omo malu ati malu: 1 bolus fun 300 kg.iwuwo ara.
Fun ẹdọ-fluke:
1 bolus fun 250 kg.iwuwo ara.
Jeki kuro ni arọwọto awọn ọmọde.
3 odun.
- Fun ẹran:12 ọjọ.
- Fun wara:4 ọjọ.
Tọju ni wiwọ itura, ibi gbigbẹ ni aabo lati ina.